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Contraindicated (1)pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with strong CYP3A4 inducers; these prescription drugs decrease exposure to vandetanib by as many as 40%.pentobarbital decreases levels of panobinostat by impacting hepatic/intesti